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Rabu, 17 Januari 2018

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Renal cell carcinoma - Wikipedia
src: upload.wikimedia.org

The Clear Cell Renal Cell Carcinoma (CCRCC) is a type of renal cell carcinoma.


Video Clear cell renal cell carcinoma



Epidemiology

  • Most commonly affects male patients in their sixties and seventies.
  • Majority of CCRCC arise sporadically.
  • Only 2 - 4% of the cases presenting as part of an inherited cancer syndrome, such as von Hippel-Lindau syndrome.

Maps Clear cell renal cell carcinoma



Microscopy

Generally, the cells have a clear cytoplasm, are surrounded by a distinct cell membrane and contain round and uniform nuclei.


Pathology Outlines - Eosinophilic variant of clear cell renal cell ...
src: farm9.staticflickr.com


Genetics

Cytogenetics

  • Alterations of chromosome 3p segments occurs in 70 - 90% of CCRCCs
  • Inactivation of von Hippel-Lindau disease (VHL) gene by gene mutation and promoter hypermethylation
  • Gain of chromosome 5q
  • Loss of chromosomes 8p, 9p, and 14q

Molecular genetics

Several frequently mutated genes were discovered in CCRCC: VHL, KDM6A/UTX, SETD2, KDM5C/JARID1C and MLL2. PBRM1 is also commonly mutated in CCRCC.


Pathology Outlines - Clear cell papillary renal cell carcinoma
src: www.pathologyoutlines.com


Histogenesis

CCRCC is derived from the proximal convoluted tubule.


Pathology Outlines - Eosinophilic variant of clear cell renal cell ...
src: farm9.staticflickr.com


Images

Source of the article : Wikipedia

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